Roland Grenningloh Selected Research

evobrutinib

1/2020	Safety, Tolerability, Pharmacokinetics, Target Occupancy, and Concentration-QT Analysis of the Novel BTK Inhibitor Evobrutinib in Healthy Volunteers.
12/2019	Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases.
1/2019	Efficacy and Pharmacodynamic Modeling of the BTK Inhibitor Evobrutinib in Autoimmune Disease Models.

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Roland Grenningloh Research Topics

Disease

6	Autoimmune Diseases (Autoimmune Disease) 01/2020 - 11/2007
5	Neoplasms (Cancer) 12/2019 - 01/2018
2	Demyelinating Diseases (Demyelinating Disease) 10/2020 - 10/2020
2	Rheumatoid Arthritis 12/2019 - 01/2019
2	Systemic Lupus Erythematosus (Libman-Sacks Disease) 12/2019 - 01/2019
2	Nephritis 03/2016 - 01/2014
2	Inflammation (Inflammations) 01/2014 - 05/2006
2	Asthma (Bronchial Asthma) 05/2006 - 04/2006
2	Pneumonia (Pneumonitis) 05/2006 - 04/2006
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2021
1	Immune System Diseases (Immune Disorders) 12/2019
1	Multiple Sclerosis 12/2019
1	Headache (Headaches) 07/2019
1	Injection Site Reaction 07/2019
1	Pruritus (Itching) 07/2019
1	Psoriasis (Pustulosis Palmaris et Plantaris) 07/2019
1	Arthritis (Polyarthritis) 03/2016
1	Proteinuria 01/2014
1	Lupus Nephritis 01/2014
1	Fibrosis (Cirrhosis) 01/2014
1	Virus Diseases (Viral Diseases) 01/2011
1	Atopic Dermatitis (Atopic Eczema) 05/2006
1	Respiratory Hypersensitivity 04/2006

Drug/Important Bio-Agent (IBA)

6	Agammaglobulinaemia Tyrosine KinaseIBA 10/2020 - 03/2016
3	evobrutinibIBA 01/2020 - 01/2019
3	Fc Receptors (Fc Receptor)IBA 01/2020 - 03/2016
3	ibrutinibIBA 12/2019 - 01/2018
2	EnzymesIBA 07/2019 - 04/2006
2	Adenosine Triphosphate (ATP)IBA 11/2018 - 01/2018
2	AutoantibodiesIBA 03/2016 - 01/2014
1	Peptides (Polypeptides)IBA 01/2021
1	Freund's AdjuvantIBA 01/2021
1	Proteins (Proteins, Gene)FDA Link 01/2021
1	Lysophosphatidylcholines (Lysophosphatidylcholine)IBA 10/2020
1	Interleukin-17 (Interleukin 17)IBA 07/2019
1	pristane (pristan)IBA 03/2016
1	Mycophenolic Acid (Cellcept)FDA LinkGeneric 01/2014
1	Pharmaceutical PreparationsIBA 01/2014
1	Immunosuppressive Agents (Immunosuppressants)IBA 01/2014
1	Antigen-Antibody Complex (Immune Complex)IBA 01/2014
1	Interleukin-7 (Interleukin 7)IBA 01/2011
1	Transcription Factors (Transcription Factor)IBA 11/2007
1	Retinoid X Receptors (Retinoid X Receptor)IBA 05/2006
1	Immunoglobulin E (IgE)IBA 04/2006
1	Methacholine Chloride (Methacholine)FDA Link 04/2006
1	cysteinyl-leukotrieneIBA 04/2006
1	Leukotriene C4IBA 04/2006
1	Immunoglobulin G (IgG)IBA 04/2006
1	Messenger RNA (mRNA)IBA 04/2006
1	LeukotrienesIBA 04/2006
1	CytokinesIBA 04/2006
1	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 04/2006

Therapy/Procedure

2	Therapeutics 01/2014 - 05/2006